Important Safety Information about Natazia

Women over 35 years old who smoke should not use Natazia. Smoking increases the risk of serious cardiovascular side effects from Natazia use. This risk increases with age and the number of cigarettes smoked.


Help your patients save on Natazia®

Pay as little as $0 up to a maximum savings of $125 for insured, covered patients, or up to $75 off each prescription for all other patients.

Bayer Savings Card

Restrictions apply. Void where prohibited by law. Bayer retains the right to rescind, revoke or amend this program without notice. Not valid for patients eligible for benefits under Medicaid (including Medicaid managed care), Medicare, TRICARE, Veterans Affairs, FEHBP, or similar state or federal programs. Offer good only in the USA and in Puerto Rico. See for additional details.



Natazia is indicated for use by women to prevent pregnancy.

Natazia is also indicated for the treatment of heavy menstrual bleeding in women without organic pathology who choose to use an oral contraceptive as their method of birth control.

The contraceptive efficacy of Natazia in women with a body mass index (BMI) of
>30 kg/m2 has not been evaluated.

Important Safety Information about Natazia

Women over 35 years old who smoke should not use Natazia. Smoking increases the risk of serious cardiovascular side effects from Natazia use. This risk increases with age and the number of cigarettes smoked.

Patients who should not take Natazia

Natazia should not be used in women with a high risk of arterial or venous thrombotic diseases, undiagnosed abnormal uterine bleeding, breast cancer or other estrogen- or progestin-sensitive cancer, liver tumors (benign or malignant) or liver disease, or who are pregnant.

Know the most serious risks

Thromboembolic and Other Vascular Events: Stop Natazia if an arterial or venous thrombotic event occurs. The risk of venous thromboembolism (VTE) is highest during the first year of combination oral contraceptive (COC) use. This increased risk is greatest after initially starting a COC or restarting the same or a different COC following a 4 week or greater
pill-free interval.

COC use also increases the risk of arterial thromboses (eg, stroke and myocardial infarction) especially in women with other risk factors for these events. If feasible, stop Natazia at least 4 weeks before and through 2 weeks after major surgery or other surgeries known to have an elevated risk of thromboembolism. Start Natazia no earlier than 4 weeks after delivery, in women who are not breastfeeding. COCs must be used with caution in women with cardiovascular disease risk factors.

Liver Disease: Discontinue Natazia if jaundice develops. Hepatic adenomas are associated with COC use.

High Blood Pressure (BP): For women with well-controlled hypertension, monitor blood pressure and stop Natazia if blood pressure rises significantly. Women with uncontrolled hypertension or hypertension with vascular disease should not use COCs. An increase in blood pressure has been reported in women taking COCs, and this increase is more likely in older women and with extended duration of use.

Carbohydrate and Lipid Metabolic Effects: Carefully monitor prediabetic and diabetic COC users. Consider alternative contraception for women with uncontrolled dyslipidemia.

Headache: If a Natazia user develops new headaches that are recurrent, persistent, or severe, evaluate the cause and discontinue Natazia if indicated. Increased frequency or severity of migraines may be reason for immediate discontinuation.

Bleeding Irregularities: If irregular bleeding persists or occurs after previously regular cycles, check for causes such as pregnancy or malignancy. Rule out pregnancy in the event of amenorrhea occurring in 2 or more consecutive cycles.

Drug Interactions: Women taking strong CYP3A4 inducers (eg, carbamazepine, phenytoin, rifampicin, and St. John's wort) should not use Natazia during and for at least 28 days after discontinuation of these inducers due to the possibility of decreased contraceptive efficacy.

Counsel patients that Natazia does not protect against HIV infection and other sexually transmitted diseases.

Serious adverse reactions in clinical trials

Myocardial infarction, ruptured ovarian cyst, deep vein thrombosis, focal nodular hyperplasia of the liver, uterine leiomyoma, acute cholecystitis, and chronic acalculous cholecystitis.

Most common adverse reactions (≥2%) in clinical trials

Headache (including migraines) (12.7%), breast pain, discomfort or tenderness (7.0%), menstrual disorders (6.9%), nausea or vomiting (6.0%), acne (3.9%), mood changes (3.0%), and increased weight (2.9%).

Please see full Prescribing Information about Natazia, including Boxed Warning.

You are encouraged to report side effects or quality complaints of products to the FDA by visiting or calling 1-800-FDA-1088.

You are now leaving the Website.

Bayer is not responsible for the content presented by any independent Website, including any advertising claims, special offers, illustrations, names or endorsements.

Thank you for visiting

OK Cancel

You are leaving a Bayer HealthCare Pharmaceuticals, Inc. website...

and going to a third party site to activate or download the Bayer Savings Card. That site may have a privacy policy different from Bayer.

Do you want to go to the third party site to activate or download a Bayer Savings Card?

Yes I want to activate/download my Bayer Savings Card Cancel